Prof. Dr. Laurent Excoffier

Head of the Population Genetics division

Phone
+41 31 631 30 31
E-Mail
laurent.excoffier@iee.unibe.ch
Office
D303
Postal Address
Institute of Ecology and Evolution
University of Bern
Baltzerstrasse 6
CH-3012 Bern

Research interests

I am interested in the development of computational methods to understand evolutionary processes at the population and species level, for instance to study how past climatic and environmental changes have influenced the pattern of genetic diversity of a given species, or to detect evidence of local adaptations from genomic information.

I have been recently studying the effect of complex demography on the molecular genetic diversity of a species, for instance such as after a spatial expansion in a heterogeneous environment. I am therefore investigating how various aspects of a species genetic diversity are influenced by historical and spatial constraints, and how these effects contrast with those of selection. We are thus aiming at designing better tests of selective neutrality, taking into account the potentially complex demographic history of a species.

With Stephan Peischl, we have been recently investigating the effect of spatial range expansion on non-neutral (functional) diversity, evidencing the buildup of a mutation load due to inefficient purifying selection on wave fronts. We are testing these theoretical predictions by studying the genomic diversity of populations having gone through recent range expansions like humans and bacteria. 

I am also involved in the development of statistical methods, which rely on massive computer simulations, to reconstruct the past demography of a species from its genetic diversity, and to test among various alternative evolutionary scenarios. I have recently switched focus from Approximate Bayesian Computations (ABC) methods to composite-likelihood methods based on the Site Frequency Spectrum (SFS)  to make inference from genomic data. I have specifically developed the fastsimcoal2 software package to both simulate genomic data and perform demographic inference. These developments are mainly applied to the reconstruction of past human history, using current and ancient genomic data, but it could be applied to any other species.

I am finally still devoting quite some time to the maintenance and extension of various computer programs listed here, including the popular program Arlequin for the analysis of population genetics data.

Curriculum vitae

Publication list on ORCID ID: orcid.org/0000-0002-7507-6494
Publication list on ResearcherID: http://www.researcherid.com/rid/D-3498-2013 

Year Activity
2001- Professor of Population Genetics, University of Berne
2020-2022 Acting Director of the Institute of Ecology and Evolution, University of Berne
2017.11 - 2018.02 Miller Visiting Professor at UC Berkeley, USA
2017.08 - 2017.11 Visiting Professor at the Institut Pasteur, Paris
2015-2018 Guest Professor, National Institute of Genetics, Mishima, Japan (annual one week visits).
2012-2014 Director of the Institute of Ecology and Evolution, University of Berne
2011.01 - 2011.07 Visiting Professor, Hospital Ste-Justine, University of Montreal, Canada
2008- Group leader at the Swiss Institute of Bioinformatics (SIB)
2007-2011 Guest Professor, Center for Computational and Evolutionary Biology, Chinese Academy of Sciences, Beijing, China
2006-2008  Head of Biology Department, University of Berne
1995-2001 Maître d'Enseignement et de Recherche, Dept.of Anthropology, University of Geneva
1991-1995 Maître assistant, Dept. of Anthropology, University of Geneva
1990-1991
Post-doc, Center for Theoretical and Applied Genetics, Rutgers University, USA
1989-1990
Associate professor, Dept. of Biological Anthropology, Musée de l'Homme, Paris,France
1988-1989
Assistant, Dept.of Anthropology, University of Geneva
1983-1988
Ph.D. studies, Dept.of Anthropology, University of Geneva
1985-1986 Certificate in Numerical Computing, University of Geneva
1979-1983
Biology undergraduate studies, University of Geneva

Selected publications